Health Tech Medtech Biotech Technologies

1. Papyrus technology:

A visualisation software to help regulators, researchers, and analysts efficiently extract insight from large collections of documents by enabling interactive exploration, focused search, and rapid screening with AI-driven visual analytics
But we can also be more specific to support the systematic literature review:
Papyrus-SLR is a visualization software designed for researchers, epidemiologists, public health agencies, regulatory bodies or pharmaceutical industry to improve the efficiency, reproducibility, and reliability of systematic literature reviews. By taking advantage of interactive data visualizations and AI, you can

explore a large paper collection
identify the most relevant areas within a topic
formulate a focused but comprehensive literature search
screen the papers quickly and make fast decisions about the inclusion or exclusion of papers.

Click here and here for more information on the technology and the project.

2. SPECTRUM technology and applications:

SPECTRUM is a next-generation sensor designed to identify ultra-low concentrations of molecules. Unlike conventional chemical detection techniques, SPECTRUM is a robust, customizable, and scalable solution that can be used across healthcare, pharma, food safety, environmental monitoring, and security, among other fields.
With the possibility of testing in-house and on-site, customization, and strategic collaboration with hospitals (CHL), research institutions (Politecnico di Milano, LIST), and industry experts (Thermo Fisher, Merck), we are shaping a solution that the market needs.

With a €500K initial raise, a strong scientific and operational team, and firm industry partnerships, SPECTRUM is positioned to capture a significant share in the $34B chemical sensor market.

Click here for more information.

3. Mot.io

Mot.io is a telerehabilitation platform designed to empower physiotherapists with advanced tools for remote patient care. Our system enhances the clinical workflow and therapeutic outcomes through the following key features:

Real-Time Kinematic Tracking: Employs a system of wearable Inertial Measurement Units (IMUs) to provide a synchronous, 3D avatar-based visualization of patient movements during home exercise programs.
Enhanced Visual Analysis: Offers clinicians full Pan-Tilt-Zoom control of the 3D avatar, enabling a detailed assessment of joint articulation, posture, and movement quality from any perspective, overcoming the limitations of standard video calls.
Data-Driven Clinical Insights: Automatically analyzes session data to generate objective performance reports. These quantitative metrics support evidence-based practice, monitor progress over time, and justify clinical decisions.
Improved Therapeutic Efficacy: The ability to provide immediate, specific feedback allows for real-time correction of exercise form, which can enhance motor learning, improve patient adherence, and accelerate recovery.
Streamlined Clinical Workflow: Our patented, user-friendly IMU calibration process simplifies at-home setup, ensuring reliable data capture with minimal patient burden. This efficiency allows a single clinician to effectively monitor multiple patients, increasing care capacity.

Click here for more information.

4. ElectroPep (Next-generation ELECTROchemical PEPtide microarrays for high-throughput protein screening)

ElectroPep is a next-generation peptide microarray platform designed for ultra-fast, high-density screening of peptide–target interactions. Unlike conventional technologies, ElectroPep synthesizes linear peptides directly on a chip by independently controlling electrochemically the acidity on each single microarray element and detects binding events label-free through integrated field-effect transistor (FET) sensors. This enables real-time, quantitative affinity data with turnaround in under a week, significantly less than traditional technologies. The platform is suited to generate high-quality datasets to support AI models for immunogenicity, binding affinity, and off-target toxicity prediction. ElectroPep positions itself as a foundational tool for AI-driven peptide drug discovery, offering licensing and data access to pharma and biotech. Commercial directions include curated dataset licensing and partnerships with immunotherapy and AI-first drug discovery companies.

A video about the ElectroPep technology is available here. Click here and here for more information on the technology and the project.

5. Invitrolize

Invitrolize is a LIST spin-off commercializing services based on the LIST’s technology ALIsens, which is an in vitro cellular model for inhalation toxicology.

Visit the website here.

6. NanoSES (Nanosensors for surface enhanced spectroscopy)

NANOSENS represents a set of enabling technologies for molecular sensing that is widely applicable for biology, environment, security, agriculture, food & beverage sectors. This includes miniaturized sensors to detect analytes, discovery of material parameters for accelerated R&D of biological interfaces, and tools to engineer material surfaces at the molecular level. These technologies bring unprecedented opportunities to control or interrogate material’s interaction with its environment. They further promise low-cost, scalable tools to deliver material interfaces engineered for end-user determined outcomes.

DEMO:

SES technology that enables sensing molecules at ultrahigh sensitivity of one or multiple markers, with quick response times, using miniaturized, hand-held devices.
Nano-QCM technology that enables design of biologically relevant materials, giving critical inputs to ‘engineer’ at the molecular level. This would enable accelerating R&D efforts, through quicker discovery of parameters that make biodevices/biointerfaces successful in any given context.
Nano-Molds that would allow creating nanostructures to engineer sensor surfaces at the molecular level, by replicating nanoscale stamps, or molds in a process akin to waffle making.

Click here for more information.

7. Nanostructured Multifunctional Materials for Sensing (NMMS) Group, Smart Materials Unit

Miniaturized gas sensors for breath analysis
On-chip peptide microarray platform for AI-driven drug discovery
Nanoengineered Biosensors and Biointerfaces

Technology #1

Minitaruzed gas sensors for breath analysis
Reference: Renaud Leturcq

Abstract
In the Healthtech and Medtech sectors, gas sensing enables non-invasive diagnostics, personalized medicine via breath analysis, and indoor air quality monitoring in healthcare environments. LIST focuses on developing miniaturized gas sensors for integration into wearable devices and consumer products.

Our work covers the design of novel sensing materials, their lab-scale testing on relevant target gases, and their integration into multi-sensor platforms. A key example is the AMUSENS project, coordinated by LIST, where an 11-partner consortium is developing an adaptable, low-cost MEMS-based gas sensor platform for breath analysis applications. The project targets use cases such as monitoring fat loss and ketosis, tracking stress, fatigue, and workout, and detecting respiratory infections.

A video about AMUSENS project is available here.

Technology #2

On-chip peptide microarray screening platform supporting AI-driven drug
discovery
Reference: Cesar Pascual Garcia

Abstract
ElectroPep is a next-generation peptide microarray platform designed for ultra-fast, high-density screening of peptide–target interactions. Unlike conventional technologies, ElectroPep synthesizes linear peptides directly on a chip by independently controlling electrochemically the acidity on each single microarray element and detects binding events label-free through integrated field-effect transistor (FET) sensors. This enables real-time, quantitative affinity data with turnaround in under a week, significantly less than traditional technologies. The platform is suited to generate high-quality datasets to support AI models for immunogenicity, binding affinity, and off-target toxicity prediction. ElectroPep positions itself as a foundational tool for AI-driven peptide drug discovery, offering licensing and data access to pharma and biotech. Commercial directions include curated dataset licensing and partnerships with immunotherapy and AI-first drug discovery companies.

A video about the ElectroPep technology is available here.

Technology #3

Nanoengineered Biosensors and Biointerfaces (NANOSENS)
Reference: Sivashankar Krishnamoorthy

Abstract
NANOSENS represents enabling nanotechnologies for bio sensing that is widely applicable for biology, environment, security, agriculture, food & beverage sectors. This includes miniaturized plasmonic sensors to detect biomarkers (Nano-SES) and tools to accelerate R&D of biomaterials (Nano-QCM).

Nano-SES technology can help medtech companies to produce highly sensitive and miniaturized sensors in desired form-factors targeting competitive diagnostic end-goals. Nano-QCM is a unique tool help equipment manufacturers and technology developers to produce innovative nano-enabled biomaterial products tailored to end-user needs (e.g., surface-enhanced biosensors, infection-free implants, antibacterial food packaging) by reducing the R&D burden and drawing from the critical information to tweak the bio interface at the molecular level.

A video about the Nanoengineered Biosensors and Biointerfaces technology is available here.

8. Molecular Analysis

Healthtech and Medtech research require in-depth understanding on bio-molecular mechanisms by investigating ex-vivo specimens as well as in-vitro models. In this context, molecular imaging by mass spectrometry (MSI) represents a key technology thanks to its ability to extract molecular compositions directly from tissue without the need for labelling MSI. This field requires increasing performances in terms of accuracy (molecular identification), selectivity (ability to differentiate isobaric molecules), lateral resolution (ability to detect specificities at a quasi cellular scale) and sensitivity (detection of trace amounts of biomolecules). LIST has developed a significant expertise in the field of Atmospheric Pressure MALDI (Matrix Assisted Laser Desorption/Ionization) coupled to high resolution Mass Spectrometry. Beyond the use of commercially available instruments and the improvement of methodologies (from sample preparation to data treatment), LIST has developed new instrumentation based on laser-based desorption and (post)ionization. As a Research and Technology Organization, LIST collaborates with APMALDI and MS instrument vendors to bring new technologies to the market, and leads/ participate in research projects applied to cancer, dermatology or neuro-degenerative disease research with academic or private partners.

9. High resolution secondary ion mass spectrometry for biomedical application

LIST Advanced Instrumentation for Nanoanalytics group develops multimodal focused-ion-beam-based imaging platforms (FIB-SIMS) giving access to correlative investigation by directly linking SIMS with other analytical/imaging signals on the same instrument (e.g. secondary electrons (SE), back-scattered electrons (BSE), micrographs of the transmitted ion/electron beam (STIM, STEM) [1-3]. A dedicated cryo-FIB-SIMS platform operational at RT and under cryogenic conditions (down to < 145°C) facilitates the analysis of beam-sensitive samples and frozen-hydrated specimen including so called cryo lamella prepared from cells or tissues [4].

Abstract
Identifying and localizing ingested particles, drugs or biomarkers in field samples or biological model systems is an important topic in biomedical and environmental research. The opportunity to correlate tissue/cell (ultra)structure to corresponding chemical maps of the introduced materials allows to understand their intracellular fate and underlying physiological/molecular processes.

However, the smaller the test material used, e.g.
1) nanoparticles or nanocarriers administered to model systems during nanotoxicological or pharmacological exposure scenarios
2) antibodies with metallic labels for correlative cytometric, light and electron microscopical analyses
3) biomarkers, isotopically labelled drugs or molecules
the better the lateral resolution of the chemical mapping must be. The consequently lower signal from smaller voxels will oftentimes lead to inaccessibility of certain markers in cells and tissues. In this regard, the use of secondary ion mass spectrometry (SIMS) can be a powerful technique due to its high sensitivity and dynamic range and the fact that individual isotopes can be identified.
[1] Wirtz et al., Annual Review of Analytical Chemistry 12 (2019) 523-543
[2] Audinot et al., Rep. Prog. Phys. 84 (2021) 105901
[3] De Castro et al., Anal. Chem 94 (2022) 10754
[4] De Castro et al., Anal. Chem. 93 (2021) 14417–14424

AP-MALDI technology for HRMS imaging

Main Technologies
Development of advanced instrumentation for molecular imaging based on Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization (AP-MALDI) technology. This platform integrates AP-MALDI with high-resolution mass spectrometry to enable both targeted and untargeted molecular imaging of biological tissue sections.
It is specifically optimized for the spatial mapping of lipids, metabolites, and pharmaceutical compounds, with enhanced sensitivity and spatial resolution.

Abstract
Healthtech and Medtech research require in-depth understanding on bio-molecular mechanisms by investigating ex-vivo specimens as well as in-vitro models. In this context, molecular imaging by mass spectrometry (MSI) represents a key technology thanks to its ability to extract molecular compositions directly from tissue without the need for labelling MSI. This field requires increasing performances in terms of accuracy (molecular identification), selectivity (ability to differentiate isobaric molecules), lateral resolution (ability to detect specificities at a quasi-cellular scale) and sensitivity (detection of trace amounts of biomolecules). LIST has developed a significant expertise in the field of Atmospheric Pressure MALDI (Matrix Assisted Laser Desorption/Ionization) coupled to high resolution Mass Spectrometry. Beyond the use of commercially available instruments and the improvement of methodologies (from sample preparation to data treatment), LIST has developed new instrumentation based on laser-based desorption and (post)ionization. As a Research and Technology

Organization: LIST collaborates with APMALDI and MS instrument vendors to bring new technologies to the market, and leads/ participate in research projects applied to cancer, dermatology or neuro-degenerative disease research with academic or private partners.

10. Antimicrobial sponge

LIST holistic solution for antimicrobial uses is a polyvinyl alcohol, a biobased cross-linker and an antimicrobial agent-loaded nano-lignin hydrogel scaffold.
With these components, LIST has developed an antimicrobial sponge with high adsorption capabilities (percentage of swelling in water is 1000%), and antimicrobial properties. In addition is a biodegradable material.

We envision possible applications such using the sponge to remove exudate in post-surgical cases, wound dressing and 3D scaffold for cell cultures. Our technology is flexible so we can tune it to special cases.

11. Drug delivery systems

At LIST, we can provide biobased drug delivery systems based on lignin, chitosan, boric acid and calcium carbonate for applications such as antimicrobial or antioxidant coatings, materials with anti-inflammatory properties or increasing tissue regeneration.

We can also embed these drug delivery systems into oily or water formulations, into scaffolds or into coatings for healthcare and cosmetic applications.

We develop the tools to produce and up-scale these materials and devices based on colloidal engineering, continuous flow processes, wet stirred media milling, spray drying and spray coating.

12. BioIMPACT (Biological Innovations for Managing Peri-implantitis with plasma Anti-biofilm Coating Technology)

BioIMPAC provides anti-biofilm properties to supra-implant dental structures (where peri-implantitis starts) as a solution to prevent or to manage and heal peri-implantitis.

Analytical imaging capabilities:

LIST provides also unique analytical imaging capabilities to study biological samples:

Atmospheric Pressure Matrix Assisted Laser Desorption / Ionization coupled to High Resolution Mass Spectrometry (targeted and untargeted molecular imaging for biological tissue sections, imaging of lipids, metabolites, drugs)
Elemental and isotopic imaging by Secondary Ion Mass Spectrometry (isotopically enriched drug detection in tissue/cells by NanoSIMS,
Immunohistochemistry imaging by mass spectrometry
Multimodal imaging based on MS and non-MS detection (Immunofluorescence, FISH, electron microscopy)
Statistical data evaluation and image fusion
New instrumentation for molecular imaging

Our technologies already contribute to research in dermatology, biomarker discovery, inflammatory diseases, toxicology, DMPK.

13. H2020 Harmonic project

In order to reduce the radiation dose to the pediatric patient, LIST helps interventional cardiologists to prepare difficult cases: With Computer Vision (all AI based nowadays) we prepare personalized 3D reconstructions and the clinical experts can examine the patient data then better, including the visualisation in Mixed Reality (using a Microsoft Hololens, for example). That helps to reduce doses, as experts are more familiar with the anatomy and do not take the wrong stents, for example.

Visit the website here.

14. HealthyW8 project

Empowering healthy lifestyle behaviour through personalised intervention portfolios to prevent and control obesity during vulnerable stages of life

This project, coordinated by LIH, aims at developing a digital-based healthy lifestyle recommender for which LIST will contribute at 3 levels:

the coordination of the co-creation process to specify new features in the meal recommender for better personalisation and recommendations for the overweight prevention,
the management of their implementation,
the contribution to a Human Digital Twin with a focus on exploring and modelling relationships between eating behaviour, personality traits and emotions

Visit the website here.

15. ARIANE project : Multilayer Network Visualization for COVID Contact tracing

We developed a Multilayer network visualization tool to support contact tracing by epidemiologists.

This demo shows a synthetic set 300,000 individuals, approximately 10% of which are covid positive cases. A multilayer graph structure is built and analysed for components of related cases where transmission between cases may have occurred in a specific time frame.

16. Acting Now FNR project: Supply Chain for the Medical Sector

More information on the project can be found here.

Videos illustrating control tower features for the early identification of distress in logistics networks and essential supply chains:
• Video 1
• Video 2

17. REACH project

A project carried out in collaboration with the environment unit at LIT to develop a platform to help manage the risk associated with toxic products.