Post-doctoral Researcher in Mass Spectrometry Imaging applied to the study of skin inflammation (M/F)

Reference : MRT-2020-034

Type: Researcher
Contract type: Fixed term contract
Duration: 24 months
Place: Belvaux



The Materials Research and Technology (MRT) Department of the Luxembourg Institute of Science and Technology (LIST) is seeking to appoint a Core Technologies Leader to support the department strategy that aims at leveraging scientific results towards science-based technology innovation. As part of a Research and Technology Organization (RTO), the Materials Research and Technology Department develops Key Enabling Technologies (KETs) that underpin a wide range of products in strategic EU value chains and provide innovative solutions to societal challenges. MRT mainly addressed three EU KETs: Nanotechnology, Advanced Materials and Advanced Manufacturing and focused its research on “new or improved” materials that provide a distinct performance advantage in comparison to the commonly used materials. Activities embrace the development, production or integration of advanced materials and equipment or system dedicated to the synthesis and the characterization of such materials. KETs having applications in multiple industries in both emerging and traditional sectors, this approach is particularly suitable for Luxembourg which features a significant number of large, medium-size and small industrial companies covering a broad range of sectors (transport, electronic, energy, cleantech, glass, buildings, cosmetics, metallurgy, space, equipment processing/engineering, health tech and others etc.). MRT aims at being active all along the materials value chain (from Raw Materials to semi-finished to end-products) that includes advanced capabilities in mature manufacturing, and the materials integration into advanced product technologies truly enabling the industrial innovation. In that context, the core technologies leader plays a pivotal role.

The department MRT is currently composed of about 190 collaborators and is engaged into the following activities:

  • a Research unit which focuses on “Nanomaterials and Nanotechnology”. The aim of this unit is to translate the enabling capabilities of nanotechnology/nanomaterials into application-driven solutions which take advantage of the functional properties of materials
  • a Research unit dealing with Instrumentation and process engineering in the fields of nanoanalytics instruments and surface treatments relying on process technology.
  • a Research unit investigating functional and bio-based polymers including bio-degradable and recyclable plastics, macromolecular chemistry, responsive polymers and polymers physics.
  • a Research unit studying structural composites materials with a specific focus on the design and durability of high performance and multi-functional composites based on advanced modeling expertise together with Interface engineering towards better performance and durability
  • a transversal Platform regrouping Materials Characterization and Testing, Composites manufacturing and Prototyping, which provides access to state-of the art characterization in the field of Molecular Analysis / Elemental and Isotopic Analysis / Structure, Morphology and Topography / Mechanical Testing and Accelerated Ageing / Thermal Analysis/ Composites manufacturing / Specific Prototyped high-end home-made processes and equipment

The Advanced Characterization Platform namely develops analytical imaging approaches to investigate the chemical composition of any type of material from the micrometre to nanometre scale. During the past few years we have been developing, in particular, molecular imaging based of the complementarity of Matrix-Assisted Laser Desorption/ionization coupled to High-Resolution Mass Spectrometry (MALDI HRMS) and Secondary Ion Mass Spectrometry (SIMS).

In the frame of an industrial partnership co-funded by the Fonds National de la Recherche (, with Pierre Fabre Dermo-Cosmétique, a world leader in pharmaceutics and dermo-cosmetics, we are looking for a highly motivated candidate.




The candidate will develop and apply molecular analyses methods (chromatography and imaging) applicable to biological tissue samples with a focus on skin inflammation related to UV exposure and inflammatory skin diseases.

She/he will actively participate to the development of new multi-modal imaging methodologies and data handling in interaction with the molecular analysis team. The responsibilities of the candidate will also include:

  • Sample preparation
  • Interpretation and statistical analysis of results, in close relation with pharmacologists and skin experts at Pierre Fabre Dermo-Cosmétique
  • Reporting
  • Dissemination of results (meetings and publications)
  • Active participation in conferences





  • PhD in analytical chemistry or chemistry

Required seniority

  • Experience of 3 years in analytical development in an R&D environment


  • Experience in analytical method development focused on mass spectrometry
  • Hands-on experience in chromatography, MALDI MS and MS imaging will be considered as a strong asset
  • Experience in the field of biological tissue imaging by MS and studies related to pharmaceutical/cosmetic formulations will be an asset
  • A background in pharmaceutical/cosmetic formulations will be an asset
  • Collaborative skills, proactive, taking initiative, result oriented, good organizational skills and capacity to work in an interdisciplinary environment
  • Good communication skills (oral and written)


  • Either English or French is mandatory


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Dr Nathalie VALLE
Dr Nathalie VALLE

 Gilles FRACHE


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