In the framework of its activities in environmental research, the Luxembourg Institute of Science and Technology (LIST) has developed assays, the T-Screen and the ANSA-TTR, for the detection of thyroid hormone (TH) disrupting chemicals.
The assays, developed by LIST’s researchers Arno Gutleb and doctoral student Mauricio Montano, are to be included into the newly established test panel of the European Union Network of Laboratories for the Validation of Alternative Methods (EU-Netval) at the European Commission’s Joint Research Centre (JRC) in Ispra (IT).
The LIST-developed assays form part of 16 others covering the Organisation for Economic-Co-operation and Development (OECD) conceptual framework of the thyroid hormone axis chosen to address various thyroid-disrupting modes of action. Their validation will take place over the next two years with LIST test developers supporting the respective test facilities with their expertise.
EU-Netval's mission is to “provide support for the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) validation studies that serve to assess the reliability and relevance of alternative methods that have a potential to replace, reduce, or refine the use of animals for scientific purposes.”
> Visit EU-Netval portal
> For any further information, please contact Arno Gutleb via email.